Search on: ANTIGEN, T3 
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Descriptor English:   CD3 Complex 
Descriptor Spanish:   Complejo CD3 
Descriptor Portuguese:   Complexo CD3 
Synonyms English:   CD3 Antigen
T3 Antigen
T3 Complex
Antigen, CD3
Antigen, T3
Antigens, T3
CD3 Antigens
Antigens, CD3
T3 Antigens  
Tree Number:   D23.050.301.264.894.095
D23.101.100.894.095
Definition English:   Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA). 
See Related English:   Receptors, Antigen, T-Cell
 
History Note English:   2018 (1993); use T3 ANTIGEN COMPLEX 1983-92; use ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE 1988-92 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   30831 
Unique Identifier:   D017252 

Occurrence in VHL:
 

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